Royal Free Anaesthesia department is a participating site at multiple portfolio research studies.

Portfolio studies are high-quality clinical research projects that receive support from the National Institute for Health Research (NIHR) Clinical Research Network in England. The NIHR Clinical Research Network supports researchers and the life sciences industry in developing, setting up and delivering high quality research to time and target in the NHS in England. Portfolio research projects benefit from access to NHS infrastructure for research, training, and International Standard Randomised Controlled Trial Number (ISRCTN) registration.

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Summary - RF Anaesthesia Department is a participating site in this pragmatic multicentre open randomised trial supported by data from the ongoing National Emergency Laparotomy Audit (NELA). The study looks at using protocolised cardiac output-guided haemodynamic therapy during and six hours after emergency laparotomy.

Primary outcome - 90 days mortality

Secondary outcomes - One-year mortality; length of stay in hospital and intensive care; hospital readmission within 90 days; cost effectiveness.

Principal Investigator - Dr Suehana Rahman



Summary - RF Anaesthesia Department is a participating site in this international, multi-centre, pragmatic, randomised controlled trial with open study group allocation, to determine if routine continuous positive airway pressure (CPAP) for four hours immediately after major abdominal surgery is effective prophylaxis against postoperative pneumonia, re-intubation or death.

Primary outcome - 30-days: composite endpoint of pneumonia, re-intubation or death.

Secondary outcomes - 30 days: infection, mechanical ventilation, hospital re-admission; days in critical care; duration of hospital stay; all-cause 1- year mortality; and quality adjusted life years at one year after surgery.

Principal Investigator - Dr Carlos Kidel

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Summary - PQIP aims to establish a dataset (based on the best evidence for patient risk factors, processes and outcomes) and then use it to measure and improve patient outcomes, while also answering important research questions.

The first PQIP patient study, which is sponsored by UCL, will recruit 70,000 consenting patients over four years. PQIP team will systematically measure complications, patient-reported outcomes and failure to rescue in participating hospitals. Hospitals may recruit a few patients per week or all patients within a particular surgical specialty or specialties. Once a patient has started their PQIP journey they will be followed up for one year after their procedure to assess their general health and wellbeing.

Participating hospitals will be provided with a live dashboard of their results along with quarterly and annual reports. These reports will be customized to meet the interests of different professional groups – surgeons, anaesthetists, nurses and managers.

Principal Investigator - Dr Craig Lyness

Team - HPB fellows and ICU research nurses: Helder, Glykeria, Christine and Margaret


Summary -  The OPtimisation of Peri-operaTive CardIovascular Management to Improve Surgical outcomE II (OPTIMISE II) trial is an international, multi-centre, pragmatic, randomised controlled trial with an open study group allocation, to determine whether cardiac output-guided fluid therapy, with a low dose inotrope infusion is clinically effective when compared to usual care in patients undergoing major gastrointestinal surgery.

Primary Outcomes - 30 days hospital acquired infection

Secondary Outcomes - Mortality within 180 days of randomisation, Acute kidney injury of Clavien-Dindo grade II or greater, within 30 days, Acute cardiac event of Clavien-Dindo grade II or greater, within 24 hours (safety outcome), Acute cardiac event of Clavien-Dindo grade II or greater, within 30 days (safety outcome).

Principal Investigator - Dr Marc Wittenberg

Team - ICU Research Nurses lead by Helder Filipe


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